home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410m.zip
/
M94A2355.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
3KB
|
45 lines
Document 2355
DOCN M94A2355
TI HLA type and susceptibility to HIV infection and AIDS among children in
Catalonia.
DT 9412
AU Just JJ; Casabona J; King MC; Institut de Recerca, Hospital de Sta Creu
i St Pau, Barcelona,; Spain.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):323 (abstract no. PC0224). Unique
Identifier : AIDSLINE ICA10/94370220
AB OBJECTIVE: Among children born to HIV-infected mothers, not all will
become infected, and among those that do become infected, the course of
disease is variable. The rate of vertical HIV transmission in Catalonia
is estimated to be 19%. Among HIV-infected children, the prognosis is
very poor with 15% dying within the first year of life. By 3 years of
age, the mortality rate is greater than 50%. Still, many children
survive more than 6 years. We have begun a study to determine if HLA
genotype of perinatally-exposed children influences their chances of
either becoming infected or the subsequent course of AIDS progression.
METHODS: Blood samples and clinical information from
perinatally--exposed children are being collected from four hospitals in
and around Barcelona. DNA is extracted, amplified by PCR and hybridized
with SSO's to determine genotype at class II HLA DPB1, DQB1, DQA1 and
DRB1. RESULTS: To date, 60 children have been sampled: 47 infected, 8
seroreverter and 5 indeterminate. We anticipate collecting at least 40
more infected and 50-100 more seroreverters within the next few months.
The infected children range in age from 5 months to 9 years. Fast and
slow progression groups will be determined using CD4 counts and age and
correlated with presence of specific HLA genotypes. In addition,
survival analyses will be performed for children with and without
specific HLA types. Finally, infected and seroreverter children will be
compared to assess HLA associations with serostatus. Results from these
analyses will be presented. CONCLUSION: Many studies report consistent
associations between HLA and HIV/AIDS among adults. It will be
worthwhile to know if these previously reported associations are found
among children as well.
DE Acquired Immunodeficiency Syndrome/GENETICS/MORTALITY/ *TRANSMISSION
Child, Preschool Female Follow-Up Studies Genotype Human HIV
Infections/GENETICS/MORTALITY/*TRANSMISSION HLA Antigens/*GENETICS
Infant Infant, Newborn Leukocyte Count Pregnancy Spain/EPIDEMIOLOGY
Survival Rate T4 Lymphocytes/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).